- Title
- Male sex is independently associated with faster disability accumulation in relapse-onset MS but not in primary progressive MS
- Creator
- Ribbons, Karen Ann; McElduff, Patrick; Oreja-Guevara, Celia; Petersen, Thor; Bergamaschi, Roberto; Giuliani, Giorgio; Barnett, Michael; van Pesch, Vincent; Amato, Maria-Pia; Iuliano, Gerardo; Fiol, Marcela; Slee, Mark; Boz, Cavit; Verheul, Freek; Cristiano, Edgardo; Fernandez-Bolanos, Ricardo; Saladino, Maria-Laura; Rio, Maria Edite; Cabrera-Gomez, Jose; Butzkueven, Helmut; van Munster, Erik; Braber-Moerland, Leontien Den; Spitaleri, Daniele La; Trojano, Maria; Lugaresi, Alessandra; Shaygannejad, Vahid; Gray, Orla; Deri, Norma; Alroughani, Raed; Lechner-Scott, Jeannette; Izquierdo, Guillermo; Duquette, Pierre; Girard, Marc; Grand'Maison, Francois; Hupperts, Raymond; Grammond, Pierre
- Relation
- PLoS ONE Vol. 10, Issue 6
- Publisher Link
- http://dx.doi.org/10.1371/journal.pone.0122686
- Publisher
- Public Library of Science (PLoS)
- Resource Type
- journal article
- Date
- 2015
- Description
- Background: Multiple Sclerosis is more common in women than men and females have more relapses than men. In a large international cohort we have evaluated the effect of gender on disability accumulation and disease progression to determine if male MS patients have a worse clinical outcome than females. Methods: Using the MSBase Registry, data from 15,826 MS patients from 25 countries was analysed. Changes in the severity of MS (EDSS) were compared between sexes using a repeated measures analysis in generalised linear mixed models. Kaplan-Meier analysis was used to test for sex difference in the time to reach EDSS milestones 3 and 6 and the secondary progressive MS. Results: In relapse onset MS patients (n = 14,453), males progressed significantly faster in their EDSS than females (0.133 vs 0.112 per year, P<0.001,). Females had a reduced risk of secondary progressive MS (HR (95% CI) = 0.77 (0.67 to 0.90) P = 0.001). In primary progressive MS (n = 1,373), there was a significant increase in EDSS over time in males and females (P<0.001) but there was no significant sex effect on the annualized rate of EDSS change. Conclusion: Among registrants of MSBase, male relapse-onset patients accumulate disability faster than female patients. In contrast, the rate of disability accumulation between male and female patients with primary progressive MS is similar.
- Subject
- multiple sclerosis; cancer risk factors; diagnostic medicine
- Identifier
- http://hdl.handle.net/1959.13/1342255
- Identifier
- uon:28923
- Identifier
- ISSN:1932-6203
- Rights
- © 2015 Ribbons et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Language
- eng
- Full Text
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